About the PI

Ke Zhang, Ph.D.

Principle Investigator


Dr. Ke Zhang studied X-ray crystallography in the laboratory of Zihe Rao during his B.S. at Tsinghua University. After that, he joined the Ph.D. program at Baylor College of Medicine to continue his research in X-ray crystallography. However, after the first three years of Ph.D., he realized that his research interest was actually in neurogenetics and decided to pursue a career in that direction. Thus, he switched to the laboratory of Hugo Bellen, a renowned Drosophila geneticist, to accomplish the rest of his Ph.D. In the Bellen laboratory, he learned to use Drosophila as a genetic model to study the molecular mechanisms of neurodegeneration. His thesis focused on understanding how reactive oxygen species disrupt lipid metabolism in several neurodegenerative diseases that are caused by mitochondrial defects. After graduating, he performed his postdoctoral training in the laboratories of Jeffrey Rothstein and Thomas Lloyd at Johns Hopkins School of Medicine, using human cell lines, iPS-derived neurons, and Drosophila as models to study the molecular mechanisms of amyotrophic lateral sclerosis and frontotemporal dementia.


Education and Training

2019 Postdoc Johns Hopkins University, School of Medicine, Baltimore, MD.

2013         Ph.D.        Baylor College of Medicine, Houston, TX.

2005 B.S.           Tsinghua University, Beijing, China.

Honors and Awards

2018                 Springboard Fellowship Award, Target ALS Foundation

2016                The Helen B. Taussig Research Award, Johns Hopkins School of Medicine

2014                 The Milton Safenowitz Postdoctoral Fellowship, The ALS association

Contact Information: zhang.ke@mayo.edu